Co-culture with podoplanin+ cells protects leukemic blast cells with leukemia-associated antigens in the tumor microenvironment
Identifieur interne : 001282 ( Main/Exploration ); précédent : 001281; suivant : 001283Co-culture with podoplanin+ cells protects leukemic blast cells with leukemia-associated antigens in the tumor microenvironment
Auteurs : Ji Yoon Lee [Corée du Sud] ; A-Reum Han [Corée du Sud] ; Sung-Eun Lee [Corée du Sud] ; Woo-Sung Min [Corée du Sud] ; Hee-Je Kim [Corée du Sud]Source :
- Molecular Medicine Reports [ 1791-2997 ] ; 2016.
Abstract
Podoplanin+ cells are indispensable in the tumor microenvironment. Increasing evidence suggests that podoplanin may support the growth and metastasis of solid tumors; however, to the best of our knowledge no studies have determined whether or not podoplanin serves a supportive role in acute myeloid leukemia (AML). The effects of co-culture with podoplanin+ cells on the cellular activities of the leukemic cells, such as apoptosis and cell proliferation, in addition to the expression of podoplanin in leukemic cells, were investigated. Due to the fact that genetic abnormalities are the primary cause of leukemogenesis, the overexpression of the fibromyalgia-like tyrosine kinase-3 gene in colony forming units was also examined following cell sorting. Podoplanin+ cells were found to play a protective role against apoptosis in leukemic cells and to promote cell proliferation. Tumor-associated antigens, including Wilms' tumor gene 1 and survivin, were increased when leukemic cells were co-cultured with podoplanin+ cells. In combination, the present results also suggest that podoplanin+ cells can function as stromal cells for blast cell retention in the AML tumor microenvironment.
Url:
DOI: 10.3892/mmr.2016.5009
PubMed: 27035421
PubMed Central: 4838120
Affiliations:
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Seoul 137-701, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Leukemia Research Institute, Catholic Blood and Marrow Transplantation Center, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 137-701</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="af2-mmr-13-05-3849">Severance Biomedical Science Institute, Yonsei University College of Medicine, Seoul 03722, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Severance Biomedical Science Institute, Yonsei University College of Medicine, Seoul 03722</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Han, A Reum" sort="Han, A Reum" uniqKey="Han A" first="A-Reum" last="Han">A-Reum Han</name><affiliation wicri:level="1"><nlm:aff id="af1-mmr-13-05-3849">Leukemia Research Institute, Catholic Blood and Marrow Transplantation Center, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 137-701, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Leukemia Research Institute, Catholic Blood and Marrow Transplantation Center, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 137-701</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Lee, Sung Eun" sort="Lee, Sung Eun" uniqKey="Lee S" first="Sung-Eun" last="Lee">Sung-Eun Lee</name><affiliation wicri:level="1"><nlm:aff id="af3-mmr-13-05-3849">Department of Hematology, Catholic Blood and Marrow Transplantation Center, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 137-701, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Hematology, Catholic Blood and Marrow Transplantation Center, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 137-701</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Min, Woo Sung" sort="Min, Woo Sung" uniqKey="Min W" first="Woo-Sung" last="Min">Woo-Sung Min</name><affiliation wicri:level="1"><nlm:aff id="af3-mmr-13-05-3849">Department of Hematology, Catholic Blood and Marrow Transplantation Center, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 137-701, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Hematology, Catholic Blood and Marrow Transplantation Center, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 137-701</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Kim, Hee Je" sort="Kim, Hee Je" uniqKey="Kim H" first="Hee-Je" last="Kim">Hee-Je Kim</name><affiliation wicri:level="1"><nlm:aff id="af1-mmr-13-05-3849">Leukemia Research Institute, Catholic Blood and Marrow Transplantation Center, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 137-701, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Leukemia Research Institute, Catholic Blood and Marrow Transplantation Center, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 137-701</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="af3-mmr-13-05-3849">Department of Hematology, Catholic Blood and Marrow Transplantation Center, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 137-701, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Hematology, Catholic Blood and Marrow Transplantation Center, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 137-701</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author></analytic><series><title level="j">Molecular Medicine Reports</title><idno type="ISSN">1791-2997</idno><idno type="eISSN">1791-3004</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Podoplanin<sup>+</sup> cells are indispensable in the tumor microenvironment. Increasing evidence suggests that podoplanin may support the growth and metastasis of solid tumors; however, to the best of our knowledge no studies have determined whether or not podoplanin serves a supportive role in acute myeloid leukemia (AML). The effects of co-culture with podoplanin<sup>+</sup> cells on the cellular activities of the leukemic cells, such as apoptosis and cell proliferation, in addition to the expression of podoplanin in leukemic cells, were investigated. Due to the fact that genetic abnormalities are the primary cause of leukemogenesis, the overexpression of the fibromyalgia-like tyrosine kinase-3 gene in colony forming units was also examined following cell sorting. Podoplanin<sup>+</sup> cells were found to play a protective role against apoptosis in leukemic cells and to promote cell proliferation. Tumor-associated antigens, including Wilms' tumor gene 1 and survivin, were increased when leukemic cells were co-cultured with podoplanin<sup>+</sup> cells. In combination, the present results also suggest that podoplanin<sup>+</sup> cells can function as stromal cells for blast cell retention in the AML tumor microenvironment.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Pabst, C" uniqKey="Pabst C">C Pabst</name></author><author><name sortKey="Krosl, J" uniqKey="Krosl J">J Krosl</name></author><author><name sortKey="Fares, I" uniqKey="Fares I">I Fares</name></author><author><name sortKey="Boucher, G" uniqKey="Boucher G">G Boucher</name></author><author><name sortKey="Ruel, R" uniqKey="Ruel R">R Ruel</name></author><author><name sortKey="Marinier, A" uniqKey="Marinier A">A Marinier</name></author><author><name sortKey="Lemieux, S" uniqKey="Lemieux S">S Lemieux</name></author><author><name sortKey="Hebert, J" uniqKey="Hebert J">J Hébert</name></author><author><name sortKey="Sauvageau, G" uniqKey="Sauvageau G">G 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Bendall</name></author><author><name sortKey="Kortlepel, K" uniqKey="Kortlepel K">K Kortlepel</name></author><author><name sortKey="Gottlieb, Dj" uniqKey="Gottlieb D">DJ Gottlieb</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Corée du Sud</li></country><region><li>Région capitale de Séoul</li></region><settlement><li>Séoul</li></settlement></list><tree><country name="Corée du Sud"><region name="Région capitale de Séoul"><name sortKey="Lee, Ji Yoon" sort="Lee, Ji Yoon" uniqKey="Lee J" first="Ji Yoon" last="Lee">Ji Yoon Lee</name></region><name sortKey="Han, A Reum" sort="Han, A Reum" uniqKey="Han A" first="A-Reum" last="Han">A-Reum Han</name><name sortKey="Kim, Hee Je" sort="Kim, Hee Je" uniqKey="Kim H" first="Hee-Je" last="Kim">Hee-Je Kim</name><name sortKey="Kim, Hee Je" sort="Kim, Hee Je" uniqKey="Kim H" first="Hee-Je" last="Kim">Hee-Je Kim</name><name sortKey="Lee, Ji Yoon" sort="Lee, Ji Yoon" uniqKey="Lee J" first="Ji Yoon" last="Lee">Ji Yoon Lee</name><name sortKey="Lee, Sung Eun" sort="Lee, Sung Eun" uniqKey="Lee S" first="Sung-Eun" last="Lee">Sung-Eun Lee</name><name sortKey="Min, Woo Sung" sort="Min, Woo Sung" uniqKey="Min W" first="Woo-Sung" last="Min">Woo-Sung Min</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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|type= RBID
|clé= PMC:4838120
|texte= Co-culture with podoplanin+ cells protects leukemic blast cells with leukemia-associated antigens in the tumor microenvironment
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:27035421" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a LymphedemaV1
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